Abstract Sporothrix spp. are the major dimorphic fungus associated with a type of subcutaneous mycosis, sporotrichosis. The limitation of antifungal availability and the past reports of in vitro resistance of Sporothrix spp. clinical isolates makes it important to search for new compounds with antifungal activities. In this study, we therefore evaluate the in vitro activities of complexes coordinated with Co(II) and cobalt chloride hexahydrate against clinical isolates of Sporothrix spp. Broth microdilution test was performed as per M38-A2 from CLSI (2008) in duplicate for 31 clinical isolates of Sporothrix spp. (27 S. brasiliensis e 04 S. schenckii stricto sensu). The antifungal activities of the complexes coordinated with Co(II) and cobalt chloride hexahydrate were detected at a concentration range of 32-128 µg/mL for all isolates. None of the compounds demonstrated any cytotoxicity (to macrophage cells) at the concentration of 200 µg/mL. The activity against Sporothrix spp. recorded in this study instigate the continuity of experimental studies with Co(II) to search for the mechanisms of antifungal action as well as to evaluate its interaction with the commercial antifungal drugs.

Resumo Estudos têm contribuído para a definição de importantes diretrizes acerca da conservação de documentos de arquivo e, em especial, a conservação preventiva, fomentando a discussão e a consolidação de políticas que busquem auxiliar na preservação dos acervos. Nessa perspectiva, a presente pesquisa, realizada em parceria entre o Instituto de Ciências Humanas e da Informação - curso de Arquivologia -, e a Escola de Química e Alimentos da Universidade Federal do Rio Grande, tem como objetivo avaliar possíveis ações de danos provocados pelo uso das folhas autoadesivas nos documentos textuais em suporte papel, visando contribuir com as discussões e estudos sobre a temática de conservação e preservação dos acervos. A metodologia para o desenvolvimento deste trabalho foi dividida em etapas que consistiram em: seleção da amostragem e pesquisa sobre o surgimento dos blocos autoadesivos, revisão do referencial teórico, análise dos dados coletados través da técnica de microscopia eletrônica de varredura e posterior divulgação dos resultados da pesquisa.

Abstract Studies have contributed to the definition of important guidelines on the file record keeping and in particular preventive conservation fostering discussion and the consolidation of policies that seek to assist in the preservation of collections. In this perspective the present research, which is a work in partnership between the Institute of Humanities and information - Archivology course, and the School of Chemistry and Food, Universidade Federal do Rio Grande, aims to evaluate possible actions deterioration caused by the use of self-adhesive sheets in textual paper documents, to contribute to discussions and studies on the theme of conservation and preservation of collections. The methodology for the development of this work has been divided into steps that were: the sample selection and research on the emergence of adhesive plates, review the theoretical framework, analysis of data collected slant electron microscopy technique and subsequent dissemination of research results.